{"product_id":"kir3dl1-polyclonal-antibody-bs7286","title":"KIR3DL1 Polyclonal Antibody-BS7286","description":"\u003cp\u003eKIR3DL1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS7286-50, BS7286-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P43629\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB\t1:500 - 1:2000\u003c\/p\u003e\n\n\u003cp\u003eBackground: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several \"framework\" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: KIR3DL1 polyclonal antibody detects endogenous levels of KIR3DL1 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 49 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western Blot (WB) analysis of KIR3DL1 polyclonal antibody\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: AMB11; \u003cbr\u003e\nCD158 antigen-like family member E; \u003cbr\u003e\nCD158E; \u003cbr\u003e\nCD158e antigen; \u003cbr\u003e\nCD158E1; \u003cbr\u003e\nCD158E1\/2; \u003cbr\u003e\nCD158E2; \u003cbr\u003e\nCL11; \u003cbr\u003e\nCL2; \u003cbr\u003e\nHLA-BW4-specific inhibitory NK cell receptor; \u003cbr\u003e\nKI3L1_HUMAN; \u003cbr\u003e\nkiller cell immunoglobulin like receptor; \u003cbr\u003e\nKiller cell immunoglobulin like receptor three domains , short cytoplasmic tail, 1; \u003cbr\u003e\nKiller cell immunoglobulin like receptor three domains long cytoplasmic tail 1; \u003cbr\u003e\nKiller cell immunoglobulin-like receptor 3DL1; \u003cbr\u003e\nKIR; \u003cbr\u003e\nKIR antigen 3DL1; \u003cbr\u003e\nKIR G1; \u003cbr\u003e\nKir3dl1; \u003cbr\u003e\nKIR3DS1; \u003cbr\u003e\nKirl1; \u003cbr\u003e\nKirl2; \u003cbr\u003e\nKrl1; \u003cbr\u003e\nMGC119726; \u003cbr\u003e\nMGC119728; \u003cbr\u003e\nMGC126589; \u003cbr\u003e\nMGC126591; \u003cbr\u003e\nMHC class I NK cell receptor; \u003cbr\u003e\nNatural killer associated transcript 3; \u003cbr\u003e\nNatural killer cell inhibitory receptor; \u003cbr\u003e\nNatural killer-associated transcript 3; \u003cbr\u003e\nNK receptor; \u003cbr\u003e\nNK-associated transcript 10; \u003cbr\u003e\nNK-associated transcript 3; \u003cbr\u003e\nNK-associated transcript 3delIg1; \u003cbr\u003e\nNKAT-3; \u003cbr\u003e\nNKAT10; \u003cbr\u003e\nNKAT3; \u003cbr\u003e\nNKB1; \u003cbr\u003e\nNKB1B; \u003cbr\u003e\np70 killer cell inhibitory receptor; \u003cbr\u003e\np70 natural killer cell receptor clones CL 2\/CL 11; \u003cbr\u003e\np70 natural killer cell receptor clones CL-2\/CL-11; \u003cbr\u003e\np70 NK receptor CL-2\/CL-11;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Recombinant full length Human KIR3DL1.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42923509612723,"sku":"BS7286-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42923509645491,"sku":"BS7286-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_fe2a5d8d-216e-485b-89f7-dca04927c218.jpg?v=1703850756","url":"https:\/\/afsbio.com\/products\/kir3dl1-polyclonal-antibody-bs7286","provider":"AFSBio Inc.","version":"1.0","type":"link"}