{"product_id":"kir6-2-rabbit-pab-es2676","title":"KIR6.2 rabbit pAb - ES2676","description":"\u003cp\u003eKIR6.2 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES2676-50, ES2676-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced trans\u003c\/p\u003e\n\n\u003cp\u003eAlternate Name: KCNJ11; ATP-sensitive inward rectifier potassium channel 11; IKATP; Inward rectifier K (+) channel Kir6.2; Potassium channel; inwardly rectifying subfamily J member 11\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human Kir6.2. AA range:190-239\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 40kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 3767\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q14654\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Membrane; Multi-pass membrane protein.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202091311283,"sku":"ES2676-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202091344051,"sku":"ES2676-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_4111b3c8-5f59-4b83-8fc5-8737aafe1fff.png?v=1767121662","url":"https:\/\/afsbio.com\/products\/kir6-2-rabbit-pab-es2676","provider":"AFSBio Inc.","version":"1.0","type":"link"}