{"product_id":"kiss1-polyclonal-antibody-bt-ap10709","title":"KISS1 Polyclonal Antibody - BT-AP10709","description":"\u003cp\u003eKISS1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP10709-20, BT-AP10709-50, BT-AP10709-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cancer; Cell biology; Epigenetics and nuclear signaling; Neuroscience\u003c\/p\u003e \n\n\u003cp\u003eTarget Protein: KISS1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Metastasis-suppressor KiSS-1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q15726; Mouse: Q6Y4S4; Rat: Q7TSB7\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Metastasis-suppressor KiSS-1;Kisspeptin-1 [Cleaved into: Metastin;Kisspeptin-54; Kisspeptin-14; Kisspeptin-13; Kisspeptin-10]\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 3814\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239194550451,"sku":"BT-AP10709-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239194583219,"sku":"BT-AP10709-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239194615987,"sku":"BT-AP10709-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_e5f23ec4-0297-4bd5-92ae-18b7f45f6359.png?v=1769390410","url":"https:\/\/afsbio.com\/products\/kiss1-polyclonal-antibody-bt-ap10709","provider":"AFSBio Inc.","version":"1.0","type":"link"}