{"product_id":"ko-validated-baf57-smarce1-rabbit-pab-a13353","title":"[KO Validated] BAF57\/SMARCE1 Rabbit pAb - A13353","description":"\u003cp\u003e[KO Validated] BAF57\/SMARCE1 Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A13353-20, A13353-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI\/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI\/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI\/SNF complex. Unlike most of the SWI\/SNF complex proteins, this protein has no yeast counterpart.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Polyclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF\/ICC, IP, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 47kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 50kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein (or fragment)\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 6605\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q969G3\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CSS5; BAF57; E1\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:500 - 1:1000 IF\/ICC, 1:50 - 1:200 IP, 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics Nuclear Signaling, Chromatin Remodeling.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: SMARCE1\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189556502707,"sku":"A13353-20","price":179.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189556535475,"sku":"A13353-100","price":515.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_c478d440-9622-417e-ae6f-0bb00f19b1e0.png?v=1766429762","url":"https:\/\/afsbio.com\/products\/ko-validated-baf57-smarce1-rabbit-pab-a13353","provider":"AFSBio Inc.","version":"1.0","type":"link"}