{"product_id":"ko-validated-fh-polyclonal-antibody-e-ab-92357","title":"(KO Validated) FH Polyclonal Antibody - E-AB-92357","description":"\u003cp\u003e(KO Validated) FH Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-92357-60, E-AB-92357-120, E-AB-92357-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: FH\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: FH; FMRD; HLRCC; LRCC; MCL; MCUL1; fumarate hydratase\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Metabolism, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P07954\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human FH\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 50kDa\/54kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 49KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146632921267,"sku":"E-AB-92357-60","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146632954035,"sku":"E-AB-92357-120","price":504.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146632986803,"sku":"E-AB-92357-200","price":812.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_f7d4ef5c-2d5c-4c53-b423-2d6f2ecd4707.png?v=1710298927","url":"https:\/\/afsbio.com\/products\/ko-validated-fh-polyclonal-antibody-e-ab-92357","provider":"AFSBio Inc.","version":"1.0","type":"link"}