{"product_id":"ko-validated-her2-erbb2-polyclonal-antibody-e-ab-93336","title":"(KO Validated) HER2\/ErbB2 Polyclonal Antibody - E-AB-93336","description":"\u003cp\u003e(KO Validated) HER2\/ErbB2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-93336-60, E-AB-93336-120, E-AB-93336-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: HER2\/ErbB2\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: ERBB2; CD340; HER-2; HER-2\/neu; HER2; MLN 19; NEU; NGL; TKR1; MLN19; erb-b2 receptor tyrosine kinase 2\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Immunology, Signal Transduction, Tags and Cell Markers\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P04626\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654\/Ile655, shown here. Amplification and\/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human HER2\/ErbB2\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 62kDa\/70kDa\/97kDa\/134kDa\/136kDa\/137kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 185KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146693607603,"sku":"E-AB-93336-60","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146693640371,"sku":"E-AB-93336-120","price":504.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146693673139,"sku":"E-AB-93336-200","price":812.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_a0f41344-2c7e-446d-b05a-483026bc4f2a.png?v=1710300281","url":"https:\/\/afsbio.com\/products\/ko-validated-her2-erbb2-polyclonal-antibody-e-ab-93336","provider":"AFSBio Inc.","version":"1.0","type":"link"}