{"product_id":"ko-validated-hira-polyclonal-antibody-e-ab-62250","title":"(KO Validated) HIRA Polyclonal Antibody - E-AB-62250","description":"\u003cp\u003e(KO Validated) HIRA Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-62250-60, E-AB-62250-120, E-AB-62250-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: HIRA\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: HIRA; DGCR1; TUP1; TUPLE1\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Epigenetics and Nuclear Signaling, Developmental Biology, Stem Cells\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P54198\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human HIRA (NP_003316.3).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:500-1:2000   IHC \t1:100-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 89kDa\/111kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 112kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146233577651,"sku":"E-AB-62250-60","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146233610419,"sku":"E-AB-62250-120","price":504.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146233643187,"sku":"E-AB-62250-200","price":812.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_daf96e14-3b67-4684-8584-b0b7ab52e934.png?v=1710292101","url":"https:\/\/afsbio.com\/products\/ko-validated-hira-polyclonal-antibody-e-ab-62250","provider":"AFSBio Inc.","version":"1.0","type":"link"}