{"product_id":"ko-validated-p53-polyclonal-antibody-e-ab-93317","title":"(KO Validated) p53 Polyclonal Antibody - E-AB-93317","description":"\u003cp\u003e(KO Validated) p53 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-93317-60, E-AB-93317-120, E-AB-93317-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: p53\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: TP53; BCC7; LFS1; P53; TRP53; tumor protein p53\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC, IF, IP\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P04637\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human p53\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IHC 1:50-1:200, IF 1:50-1:200, IP 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 23-43kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 53KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146692001971,"sku":"E-AB-93317-60","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146692034739,"sku":"E-AB-93317-120","price":504.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146692067507,"sku":"E-AB-93317-200","price":812.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_31663512-d235-4358-8dd2-5d79a25ed008.png?v=1710300250","url":"https:\/\/afsbio.com\/products\/ko-validated-p53-polyclonal-antibody-e-ab-93317","provider":"AFSBio Inc.","version":"1.0","type":"link"}