{"product_id":"ko-validated-ptpn2-polyclonal-antibody-e-ab-60454","title":"(KO Validated) PTPN2 Polyclonal Antibody - E-AB-60454","description":"\u003cp\u003e(KO Validated) PTPN2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-60454-60, E-AB-60454-120, E-AB-60454-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PTPN2\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: PTPN2; PTN2; PTPT; TC-PTP; TCELLPTP; TCPTP\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer,Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P17706\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human PTPN2\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IF 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 40kDa\/45kDa\/48kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 45kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146068754611,"sku":"E-AB-60454-60","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146068787379,"sku":"E-AB-60454-120","price":504.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146068820147,"sku":"E-AB-60454-200","price":812.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_f62b6f47-7a58-416b-a74e-b3928bdf4bb9.png?v=1710290704","url":"https:\/\/afsbio.com\/products\/ko-validated-ptpn2-polyclonal-antibody-e-ab-60454","provider":"AFSBio Inc.","version":"1.0","type":"link"}