{"product_id":"ko-validated-rock1-polyclonal-antibody-e-ab-62198","title":"(KO Validated) ROCK1 Polyclonal Antibody - E-AB-62198","description":"\u003cp\u003e(KO Validated) ROCK1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-62198-60, E-AB-62198-120, E-AB-62198-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ROCK1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: ROCK1; P160ROCK; ROCK-I\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q13464\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a protein serine\/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human ROCK1 (NP_005397.1).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:500-1:2000   IHC \t1:50-1:100\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 158kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 158kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146230694067,"sku":"E-AB-62198-60","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146230726835,"sku":"E-AB-62198-120","price":504.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146230759603,"sku":"E-AB-62198-200","price":812.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_63c3cd12-18f3-40c6-af01-7bd321a91309.png?v=1710292046","url":"https:\/\/afsbio.com\/products\/ko-validated-rock1-polyclonal-antibody-e-ab-62198","provider":"AFSBio Inc.","version":"1.0","type":"link"}