{"product_id":"ko-validated-setdb1-rabbit-pab-a6145","title":"[KO Validated] SETDB1 Rabbit pAb - A6145","description":"\u003cp\u003e[KO Validated] SETDB1 Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A6145-20, A6145-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Polyclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF-P, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 143kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 180kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein (or fragment) .\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 9869\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q15047\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ESET; KG1T; KMT1E; TDRD21; H3-K9-HMTase4; B1\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:500 - 1:1000 IF-P, 1:100-1:300 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics Nuclear Signaling, Epigenetic writers and erasers of core Histones.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: SETDB1\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189977243827,"sku":"A6145-20","price":179.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189977276595,"sku":"A6145-100","price":515.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_e99db153-157d-4301-933f-42f1847d9ab4.png?v=1766439152","url":"https:\/\/afsbio.com\/products\/ko-validated-setdb1-rabbit-pab-a6145","provider":"AFSBio Inc.","version":"1.0","type":"link"}