{"product_id":"ko-validated-stat5b-polyclonal-antibody-e-ab-92402","title":"(KO Validated) STAT5B Polyclonal Antibody - E-AB-92402","description":"\u003cp\u003e(KO Validated) STAT5B Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-92402-60, E-AB-92402-120, E-AB-92402-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: STAT5B\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: STAT5B; STAT5; signal transducer and activator of transcription 5B\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P51692\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human STAT5B\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IHC 1:50-1:100, IF 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 89kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 92KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146633871539,"sku":"E-AB-92402-60","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146633904307,"sku":"E-AB-92402-120","price":504.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146633937075,"sku":"E-AB-92402-200","price":812.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_53172bb4-7236-4e92-9b61-c66158d03faf.png?v=1710298951","url":"https:\/\/afsbio.com\/products\/ko-validated-stat5b-polyclonal-antibody-e-ab-92402","provider":"AFSBio Inc.","version":"1.0","type":"link"}