{"product_id":"kpci-polyclonal-antibody-bt-ap10743","title":"KPCI Polyclonal Antibody - BT-AP10743","description":"\u003cp\u003eKPCI Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP10743-20, BT-AP10743-50, BT-AP10743-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the protein kinase C (PKC) family of serine\/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD\/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Signal transduction\u003c\/p\u003e \n\n\u003cp\u003eTarget Protein: PRKCI\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Protein kinase C iota type\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P41743; Mouse: Q62074; Rat: F1M7Y5\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Protein kinase C iota type;EC 2.7.11.13;Atypical protein kinase C-lambda\/iota;PRKC-lambda\/iota;aPKC-lambda\/iota;nPKC-iota\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 5584\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239196647603,"sku":"BT-AP10743-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239196680371,"sku":"BT-AP10743-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239196713139,"sku":"BT-AP10743-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_fd69ce35-c0d3-4999-a2ad-d13ecf99c6a0.png?v=1769390444","url":"https:\/\/afsbio.com\/products\/kpci-polyclonal-antibody-bt-ap10743","provider":"AFSBio Inc.","version":"1.0","type":"link"}