{"product_id":"kpm-polyclonal-antibody-bt-ap04866","title":"Kpm Polyclonal Antibody - BT-AP04866","description":"\u003cp\u003eKpm Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP04866-20, BT-AP04866-50, BT-AP04866-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: LATS2 encodes a serine\/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: LATS2\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Kpm Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 120194\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9NRM7; Mouse: Q7TSJ6\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: LATS2; KPM; Serine\/threonine-protein kinase LATS2; Kinase phosphorylated during mitosis protein; Large tumor suppressor homolog 2; Serine\/threonine-protein kinase kpm; Warts-like kinase\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 26524; Mouse: 50523\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239651631283,"sku":"BT-AP04866-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239651664051,"sku":"BT-AP04866-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239651696819,"sku":"BT-AP04866-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_f00405ea-83f5-49f1-9041-63122f805050.png?v=1769397588","url":"https:\/\/afsbio.com\/products\/kpm-polyclonal-antibody-bt-ap04866","provider":"AFSBio Inc.","version":"1.0","type":"link"}