{"product_id":"kpna2-polyclonal-antibody-e-ab-52984","title":"KPNA2 Polyclonal Antibody - E-AB-52984","description":"\u003cp\u003eKPNA2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-52984-60, E-AB-52984-120, E-AB-52984-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: KPNA2\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: IMA1; Importin alpha 1; Importin alpha 2; Importin alpha 2 subunit; Importin alpha P1; Importin subunit alpha-1; IPO A1; IPOA 1; IPOA1; Karyopherin alpha 2; Karyopherin alpha 2 RAG cohort 1; Karyopherin alpha 2 subunit; Karyopherin subunit alpha-2; KPNA2; KPNA2 protein; Pendulin; QIP 2; QIP2; RAG cohort 1; RAG cohort protein 1; RCH 1; RCH1; SRP 1; SRP1 alpha; SRP1; SRP1-alpha; SRP1alpha\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Immunology, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P52292\u003c\/p\u003e\n\n\u003cp\u003eBackground: The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1.08 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Fusion protein of human KPNA2\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:50-1:300, ELISA 1:5000-1:10000\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43133553311923,"sku":"E-AB-52984-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43133553344691,"sku":"E-AB-52984-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43133553377459,"sku":"E-AB-52984-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_273fc4ae-7a7f-406d-89d7-957441762ad9.png?v=1709899996","url":"https:\/\/afsbio.com\/products\/kpna2-polyclonal-antibody-e-ab-52984","provider":"AFSBio Inc.","version":"1.0","type":"link"}