{"product_id":"krt15-monoclonal-antibody-bt-mca4301","title":"KRT15 Monoclonal Antibody - BT-MCA4301","description":"\u003cp\u003eKRT15 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4301-50, BT-MCA4301-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 15 is a type I keratin without a defined type II partner. Keratin 15 is expressed primarily in the basal keratinocytes of stratified tissues, including the fetal epidermis and fetal nail. Expression of keratin 15 is downregulated in some hyperproliferating situations, such as psoriasis and hypertrophic scars. Because keratinocytes in psoriasis and hypertrophic scars are activated, it is suggested that keratin 15 expression is not compatible with keratinocyte activation and the keratin 15 gene is downregulated to maintain the activated phenotype.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: KRT15\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC, ICC, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 6E7\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG2a\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: KRT15\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of KRT15 expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 49kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P19012\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: K15, CK15, K1CO, KRT1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 3866\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238631563443,"sku":"BT-MCA4301-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238631596211,"sku":"BT-MCA4301-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_c084341a-42db-453f-a08a-57cdca1c96f8.png?v=1769383241","url":"https:\/\/afsbio.com\/products\/krt15-monoclonal-antibody-bt-mca4301","provider":"AFSBio Inc.","version":"1.0","type":"link"}