{"product_id":"ksr2-rabbit-pab-es5584","title":"Ksr2 rabbit pAb - ES5584","description":"\u003cp\u003eKsr2 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES5584-50, ES5584-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: domain:The protein kinase domain is predicted to be catalytically inactive., function:Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production., PTM:Phosphorylated on Ser-474 by MARK3., similarity:Belongs to the protein kinase superfamily. TKL Ser\/Thr protein kinase family., similarity:Contains 1 phorbol-ester\/DAG-type zinc finger., similarity:Contains 1 protein kinase domain., subunit:Interacts with MAP2K1, MAP3K8, MAPK, RAS and RAF., tissue specificity:Mainly expressed in brain and kidney.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: KSR2; Kinase suppressor of Ras 2; hKSR2\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human KSR2. AA range:671-720\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 108kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 283455\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q6VAB6\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm. Membrane; Peripheral membrane protein.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202256330931,"sku":"ES5584-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202256363699,"sku":"ES5584-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_60089afe-bed8-44ce-8773-13c9418fae51.png?v=1767125214","url":"https:\/\/afsbio.com\/products\/ksr2-rabbit-pab-es5584","provider":"AFSBio Inc.","version":"1.0","type":"link"}