{"product_id":"ku-70-xrcc6-7b1-monoclonal-antibody-mb0185","title":"Ku-70\/XRCC6 (7B1) Monoclonal Antibody-MB0185","description":"\u003cp\u003eKu-70\/XRCC6 (7B1) Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB0185-50, MB0185-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P12956\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Monkey\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC IP,\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB: 1:1000\u003cbr\u003e\nIP: 1:50~200\u003cbr\u003e\nICC: 1:50~200\u003c\/p\u003e\n\n\u003cp\u003eBackground: The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (or p70) and Ku-86 (or p86), which is also known by the synonym Ku-80 (or p80). Ku was first described as an autoantigen to which antibodies were produced in a patient with scleroderma-polymyositis overlap syndrome, and was later found in the sera of patients with other rheumatic diseases. Both subunits of the Ku protein have been cloned, and a number of functions have been proposed for Ku, including cell signaling, DNA replication and transcriptional activation.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of Ku-70 and does not cross-react with related proteins.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: Predicted band size: 70KDa \u003cbr\u003e\nObserved band size: 70KDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot detection of Ku70 in Hela,A549,COS7 and K562 cell lysates using Ku70 mouse mAb (1:1000 diluted)., Immunocytochemistry staining of HeLa cells fixed with -20℃ Methanol and using anti-Ku70 antibody (dilution 1:200)., Immunoprecipitation analysis of Hela cell lysates using Ku70 mouse mAb.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: X-ray repair cross-complementing protein 6; 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; Lupus Ku autoantigen protein p70; Ku70; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in; Chinese hamster cells 6; XRCC6; G22P1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant human Ku70 protein fragments expressed in E.coli.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42997589639347,"sku":"MB0185-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42997589672115,"sku":"MB0185-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_fe96e5bd-f203-4d0b-be6c-db3fe317d295.jpg?v=1706270801","url":"https:\/\/afsbio.com\/products\/ku-70-xrcc6-7b1-monoclonal-antibody-mb0185","provider":"AFSBio Inc.","version":"1.0","type":"link"}