{"product_id":"lambda-5-polyclonal-antibody-bt-ap04931","title":"Lambda 5 Polyclonal Antibody - BT-AP04931","description":"\u003cp\u003eLambda 5 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP04931-20, BT-AP04931-50, BT-AP04931-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Lambda 5 (also called Immunoglobulin lambda-like polypeptide 1 or CD179b antigen) and VpreB comprise the surrogate light chain of the pre-B cell receptor complex. SL chain is also part of a quality control mechanism that tests a m-chain for its ability to pair with conventional L chains. It can form Ig-like complexes with the heavy (H) chain, the DHJHC m-protein or the p55 chain. Production of the surrogate light chain begins at the stage of pro-B cells, continues during the pre-B-cell stage and halts at the immature B cell stage. Once pre-BCR is expressed, SL chain expression is turned off. As pre-B II cells proliferate, SL is diluted out, thus limiting pre-BCR formation. Lambda 5 is critical for B cell development in mammals. Expression of Lambda 5 is highest in liver, pre- B-lymphocytes and bone marrow, the major source of B cell precursors.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: IGLL1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: lambda 5 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 22963\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P15814; Mouse: P20764\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: IGLL1; IGL1; Immunoglobulin lambda-like polypeptide 1; CD179 antigen-like family member B; Ig lambda-5; Immunoglobulin omega polypeptide; Immunoglobulin-related protein 14.1; CD179b\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 3543; Mouse: 16136\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239654973619,"sku":"BT-AP04931-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239655006387,"sku":"BT-AP04931-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239655039155,"sku":"BT-AP04931-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_c60a4543-fd5e-420a-ba08-e182b8e2afca.png?v=1769397643","url":"https:\/\/afsbio.com\/products\/lambda-5-polyclonal-antibody-bt-ap04931","provider":"AFSBio Inc.","version":"1.0","type":"link"}