{"product_id":"lamin-a-c-d230-polyclonal-antibody-bs7014","title":"Lamin A\/C (D230) Polyclonal Antibody-BS7014","description":"\u003cp\u003eLamin A\/C (D230) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS7014-50, BS7014-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P02545\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eBackground: Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication, and chromatin organization. Lamin A\/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A\/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment. The cleavage of lamins results in nuclear disregulation and cell death.\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Lamin A\/C (D230) polyclonal antibody detects endogenous levels of Lamin A\/C protein.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of Lamin A\/C (D230) at 1:500 dilution\u003cbr\u003e\nLane 1: AML-12 whole cell lysate (40ug)\u003cbr\u003e\nLane 2: C6 whole cell lysate (40ug)\u003cbr\u003e\nLane 3: Panc1 whole cell lysate (40ug)\u003cbr\u003e\nLane 4: H1792 whole cell lysate (40ug), Immunohistochemistry (IHC) analysis of Lamin A\/C (D230) pAb in paraffin-embedded human lung carcinoma tissue.\u003c\/p\u003e \n\n\u003cp\u003eBioworld Molecular Weight: ~ 64, 73 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Prelamin-A\/C; Lamin-A\/C; Lamin A\/C; LaminA\/C; 70 kDa lamin; Renal carcinoma antigen NY-REN-32; LMNA; LMN1; Lamin A; LaminA; Lamin-A; Lamin C; LaminC; Lamin-C\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 231-280 of Human Lamin A.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42953247129779,"sku":"BS7014-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42953247162547,"sku":"BS7014-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_3bb13ecb-9319-4c86-a93c-0bf20feac59f.jpg?v=1705057615","url":"https:\/\/afsbio.com\/products\/lamin-a-c-d230-polyclonal-antibody-bs7014","provider":"AFSBio Inc.","version":"1.0","type":"link"}