{"product_id":"lamin-a-c-monoclonal-antibody-mb12098","title":"Lamin A\/C Monoclonal Antibody-MB12098","description":"\u003cp\u003eLamin A\/C Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB12098-50, MB12098-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P02545\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-F, IHC-P, ICC\/IF\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1\/500-1\/1000  IHC: 1\/50-1\/100  IF: 1\/50-1\/200\u003c\/p\u003e  \n\n\u003cp\u003eBackground: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.\u003cbr\u003e\nPrelamin-A\/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.\u003c\/p\u003e\n\n\n\u003cp\u003ePurification and Purity: Affinity Purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IgG\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: Calculated MW: 74 kDa; Observed MW: 74,63 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Immunocytochemistry analysis of Lamin A\/C in Hela using Lamin A\/C antibody, and DAPI., Western blot analysis of Lamin A\/C in 3T3, C2C12 lysates using Lamin A\/C antibody., Western blot analysis of Lamin A\/C in U251, Lncap, A549 lysates using Lamin A\/C antibody, Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Lamin A\/C antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: LMNA; LMN1; Prelamin-A\/C\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human Lamin A\/C\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":43055912190131,"sku":"MB12098-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":43055912222899,"sku":"MB12098-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_17af50cc-2a79-42a0-9654-ea53c6e6c1e0.jpg?v=1708086630","url":"https:\/\/afsbio.com\/products\/lamin-a-c-monoclonal-antibody-mb12098","provider":"AFSBio Inc.","version":"1.0","type":"link"}