{"product_id":"lamin-a-c-phospho-s392-polyclonal-antibody-bs65001","title":"Lamin A\/C (Phospho-S392) Polyclonal Antibody-BS65001","description":"\u003cp\u003eLamin A\/C (Phospho-S392) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS65001-50, BS65001-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P02545\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:500~1:1000 IHC:1:50~1:200 IF:1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.Prelamin-A\/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.\u003c\/p\u003e \n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Lamin A\/C (Phospho-S392) polyclonal antibody detects endogenous levels of Lamin A\/C protein only when phosphorylated at Ser392.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 74, 65 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of Lamin A\/C (Phospho-S392) polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLane A: DLD whole cell lysate\u003cbr\u003e\nLane B: The Kidney tissue lysate of Mouse\u003cbr\u003e\nLane C: The Lung tissue lysate of Rat\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Prelamin-A\/C; Lamin-A\/C; Lamin A\/C; LaminA\/C; 70 kDa lamin; Renal carcinoma antigen NY-REN-32; LMNA; LMN1; Lamin A; LaminA; Lamin-A; Lamin C; LaminC; Lamin-C\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic phosphopeptide derived from human Lamin A\/C around the phosphorylation site of Serine 392.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylation\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":43044026187955,"sku":"BS65001-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":43044026220723,"sku":"BS65001-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_111376ac-e9ef-4565-be28-75a9a7e370b8.jpg?v=1707738633","url":"https:\/\/afsbio.com\/products\/lamin-a-c-phospho-s392-polyclonal-antibody-bs65001","provider":"AFSBio Inc.","version":"1.0","type":"link"}