{"product_id":"lats1-2-phospho-thr1079-1041-polyclonal-antibody-ra21132","title":"LATS1\/2 (phospho Thr1079\/1041) Polyclonal Antibody - RA21132","description":"\u003cp\u003eLATS1\/2 (phospho Thr1079\/1041) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA21132-50, RA21132-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: large tumor suppressor kinase 1 (LATS1) Homo sapiens The protein encoded by this gene is a putative serine\/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2\/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: LATS1; WARTS; Serine\/threonine-protein kinase LATS1; Large tumor suppressor homolog 1; WARTS protein kinase; h-warts; LATS2; KPM; Serine\/threonine-protein kinase LATS2; Kinase phosphorylated during mitosis protein; Large tumor suppressor ho\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p; IF (paraffin section) ; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 9113\/26524\u003c\/p\u003e\n\n\u003cp\u003eSWISS: O95835\/Q9NRM7\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45119693586611,"sku":"RA21132-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45119693619379,"sku":"RA21132-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_5a1922cc-d8c0-413c-892c-143258ee25b4.png?v=1773356066","url":"https:\/\/afsbio.com\/products\/lats1-2-phospho-thr1079-1041-polyclonal-antibody-ra21132","provider":"AFSBio Inc.","version":"1.0","type":"link"}