{"product_id":"lc3a-rabbit-pab-es20427","title":"LC3A rabbit pAb - ES20427","description":"\u003cp\u003eLC3A rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES20427-50, ES20427-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: function:Probably involved in formation of autophagosomal vacuoles (autophagosomes)., PTM:The precursor molecule is cleaved by APG4B\/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L\/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II., similarity:Belongs to the MAP1 LC3 family., subcellular location:LC3-II binds to the autophagic membranes., subunit:3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins., tissue specificity:Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: Microtubule-associated proteins 1A\/1B light chain 3A (Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; MAP1A\/MAP1B light chain 3 A; MAP1A\/MAP1B LC3 A; Microtubule-associated protein 1 light chain 3 alpha)\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA; IHC\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat; Mouse;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human LC3A\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 84557\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q9H492\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Endomembrane system; Lipid-anchor. Cytoplasm, cytoskeleton. LC3-II binds to the autophagic membranes.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45201962172595,"sku":"ES20427-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45201962205363,"sku":"ES20427-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_ab5a48a4-d84d-4a22-a0fa-98d364d0be0a.png?v=1767118935","url":"https:\/\/afsbio.com\/products\/lc3a-rabbit-pab-es20427","provider":"AFSBio Inc.","version":"1.0","type":"link"}