{"product_id":"ldlr-polyclonal-antibody-bt-ap10875","title":"LDLR Polyclonal Antibody - BT-AP10875","description":"\u003cp\u003eLDLR Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP10875-20, BT-AP10875-50, BT-AP10875-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer; Cardiovascular; Metabolism; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: LDLR\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Low-density lipoprotein receptor\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P01130; Mouse: P35951; Rat: P35952\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Low-density lipoprotein receptor;LDL receptor\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 3949\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239202119859,"sku":"BT-AP10875-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239202152627,"sku":"BT-AP10875-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239202185395,"sku":"BT-AP10875-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_0aefa289-f8ff-472a-96c0-7334f121eae8.png?v=1769390529","url":"https:\/\/afsbio.com\/products\/ldlr-polyclonal-antibody-bt-ap10875","provider":"AFSBio Inc.","version":"1.0","type":"link"}