{"product_id":"lgals3-polyclonal-antibody-e-ab-40655","title":"Lgals3 Polyclonal Antibody - E-AB-40655","description":"\u003cp\u003eLgals3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-40655-50, E-AB-40655-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Lgals3\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: LGALS3; MAC2; Galectin-3; Gal-3; 35 kDa lectin; CBP 35; Galactose-specific lectin 3; GALBP; IgE-binding protein; L-31; Laminin-binding protein; Lectin L-29; Mac-2 antigen\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Neuroscience, Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P08699\u003c\/p\u003e\n\n\u003cp\u003eBackground: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1.7mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant Rat Lgals3 protein expressed by E.coli\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH 7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen Affinity Purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB:1:250-1:500\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 26kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 28kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"50μL","offer_id":43149047759027,"sku":"E-AB-40655-50","price":175.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":43149047791795,"sku":"E-AB-40655-100","price":322.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_451161ac-85eb-4681-bc96-54d3a09574d9.png?v=1710339223","url":"https:\/\/afsbio.com\/products\/lgals3-polyclonal-antibody-e-ab-40655","provider":"AFSBio Inc.","version":"1.0","type":"link"}