{"product_id":"lgmn-polyclonal-antibody-bt-ap10892","title":"LGMN Polyclonal Antibody - BT-AP10892","description":"\u003cp\u003eLGMN Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP10892-20, BT-AP10892-50, BT-AP10892-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal\/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cancer; Cell biology; Immunology; Metabolism; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: LGMN\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Legumain\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q99538; Mouse: O89017; Rat: Q9R0J8\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Legumain;EC 3.4.22.34;Asparaginyl endopeptidase;Protease, cysteine 1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 5641\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239202611379,"sku":"BT-AP10892-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239202644147,"sku":"BT-AP10892-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239202676915,"sku":"BT-AP10892-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_67d6cfab-d17a-4189-a9dc-76446d158bac.png?v=1769390537","url":"https:\/\/afsbio.com\/products\/lgmn-polyclonal-antibody-bt-ap10892","provider":"AFSBio Inc.","version":"1.0","type":"link"}