{"product_id":"lgr5-rabbit-polyclonal-antibody-es11504","title":"LGR5 Rabbit Polyclonal Antibody - ES11504","description":"\u003cp\u003eLGR5 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES11504-50, ES11504-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: approximately 7-10 business days, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015],\u003c\/p\u003e \n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from part region of human protein\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: LGR5,\u003c\/p\u003e \n\n\u003cp\u003eSpecificity: LGR5 Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e \n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver.\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 99kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Wnt signaling pathway\u003c\/p\u003e\n\n\u003cp\u003eFunction: Orphan receptor. It may be an important receptor for signals controlling growth and differentiation of specific embryonic tissues. Similarity: Belongs to the G-protein coupled receptor 1 family. Similarity: Contains 17 LRR (leucine-rich) repeats. Tissue Specificity: Expressed in skeletal muscle, placenta, spinal cord, and various region of brain.\u003c\/p\u003e \n\n\u003cp\u003eSubcellular Location: Cell membrane, Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane, Multi-pass membrane protein. Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864, however, the phosphorylation event has not been proven (PubMed:23439653).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: LGR5, GPR49, GPR67\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Leucine-rich repeat-containing G-protein coupled receptor 5, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 8549\u003c\/p\u003e\n\n\u003cp\u003eHuman SwissProt Number: O75473\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q9Z1P4\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":45825497104563,"sku":"ES11504-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45825497137331,"sku":"ES11504-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk-biotechnology-logo-product.jpg?v=1786476023","url":"https:\/\/afsbio.com\/products\/lgr5-rabbit-polyclonal-antibody-es11504","provider":"AFSBio Inc.","version":"1.0","type":"link"}