{"product_id":"lim-and-sh3-domain-protein-1-rabbit-polyclonal-antibody-es8817","title":"LIM and SH3 domain Protein 1 Rabbit Polyclonal Antibody - ES8817","description":"\u003cp\u003eLIM and SH3 domain Protein 1 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES8817-50, ES8817-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50)\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human LIM and SH3 domain protein 1. at AA range: 90-130\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: LIM and SH3 domain protein 1\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of LIM and SH3 domain protein 1\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000, IHC-p 1:50-300\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Epithelium, Liver, Mammary carcinoma, Platelet, Skin, T-cell,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 38kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types\u003cbr\u003e\nPTM: Phosphorylated\u003cbr\u003e\nSimilarity: Contains 1 LIM zinc-binding domain\u003cbr\u003e\nSimilarity: Contains 1 SH3 domain\u003cbr\u003e\nSimilarity: Contains 2 nebulin repeats\u003cbr\u003e\nSubcellular Location: Associated with the F-actin rich cortical cytoskeleton\u003cbr\u003e\nSubunit: Interacts with F-actin\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cytoplasm, cell cortex Cytoplasm, cytoskeleton Associated with the F-actin rich cortical cytoskeleton\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: LASP1 MLN50\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: LIM and SH3 domain protein 1\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 16796\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q61792\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313887793331,"sku":"ES8817-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313887826099,"sku":"ES8817-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/lim-and-sh3-domain-protein-1-rabbit-polyclonal-antibody-es8817","provider":"AFSBio Inc.","version":"1.0","type":"link"}