{"product_id":"limk1-monoclonal-antibody-mb67021","title":"LIMK1 Monoclonal Antibody - MB67021","description":"\u003cp\u003eLIMK1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB67021-50, MB67021-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: LIM kinases (LIMK1 and LIMK2) are serine\/threonine kinases that have two zinc finger motifs, known as LIM motifs, in their amino-terminal regμlatory domains . LIM kinases are involved in actin cytoskeletal regμlation downstream of Rho-family GTPases, PAKs, and ROCK . PAK1 and ROCK phosphorylate LIMK1 or LIMK2 at the conserved Thr508 or Thr505 residues in the activation loop, increasing LIMK activity . Activated LIM kinases inhibit the actin depolymerization activity of cofilin by phosphorylation at the amino-terminal Ser3 residue of cofilin .\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: LIMK, LIM domain kinase 1, LIMK-1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human LIMK1. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB (1\/500 - 1\/1000)\u003c\/p\u003e\n\n\u003cp\u003ePurification: This antibody is purified through a protein G column.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of LIMK1 protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 70 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Regμlation of Actin Dynamics, Regμlation of Microtubμle Dynamics, TGFβ Smad signaling.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P53667\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgM kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946428752051,"sku":"MB67021-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946428784819,"sku":"MB67021-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/limk1-monoclonal-antibody-mb67021","provider":"AFSBio Inc.","version":"1.0","type":"link"}