{"product_id":"litaf-polyclonal-antibody-bt-ap10930","title":"LITAF Polyclonal Antibody - BT-AP10930","description":"\u003cp\u003eLITAF Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP10930-20, BT-AP10930-50, BT-AP10930-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Pagetandapos;s disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: LITAF\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Lipopolysaccharide-induced tumor necrosis factor-alpha factor\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q99732; Mouse: Q9JLJ0; Rat: P0C0T0\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Lipopolysaccharide-induced tumor necrosis factor-alpha factor;LPS-induced TNF-alpha factor;Small integral membrane protein of lysosome\/late endosome;p53-induced gene 7 protein\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 9516\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239204020403,"sku":"BT-AP10930-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239204053171,"sku":"BT-AP10930-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239204085939,"sku":"BT-AP10930-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_ac9bf5fc-db20-4da0-acaf-9f430856d939.png?v=1769390561","url":"https:\/\/afsbio.com\/products\/litaf-polyclonal-antibody-bt-ap10930","provider":"AFSBio Inc.","version":"1.0","type":"link"}