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Liver Cytosol 1 - 0.2mg

Liver Cytosol 1 - 0.2mg

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$517.04 USD
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Liver cytosol antigen 1
formiminotransferase cyclodeaminase

Uniprot ID:  O95954
mRNA RefSeq:  NM_006657.2 NM_206965.1 
Protein RefSeq:  NP_006648.1 NP_996848.1
Size: 0.2mg
Source: Recombinant
Catalogue Number: ATL04-02

Product Information

LC-1 is a marker for autoimmune hepatitis (AIH) type II and antibodies against LC-1 are found to be detected in up to 50% of cases. Immunofluorescence of LC-1 is often not identified due to the brightness of LKM-1 obscuring accurate visualisation. Some occurrences of anti-LC-1 in conjunction with antinuclear antibodies (ANA) and smooth muscle antibodies (SMA) in patients with chronic hepatitis C and autoimmune hepatitis, is known. Some case studies have shown that anti-LC-1 is found as the only serological marker in patients with AIH type II.

The antigen recognised by LC-1 antibodies has been identified as formiminotransferase cyclodeaminase (FTCD). FTCD is a bifunctional enzyme which consists of 8 identical molecular subunits of 60 kDa each arranged in a circular tetramer of dimers. FTCD catalyses two independent but sequential reactions in the histidine degradation pathway in the mammalian liver. Each subunit consists of an N-terminal transferase active domain and a C-terminal deaminase active domain. The dimers are responsible for the separate activities of both the transferase and deaminase activity.

PDF-logo-dl Liver Cytosol 1 datasheet

Clinical Indications

Autoimmune Hepatitis


PDF-logo-dl  Material Safety Data Sheet


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Muratori L et al., (1995) Detection of anti-liver cytosol antibody type 1 (anti-LC1) by immunodiffusion, counterimmunoelectrophoresis and immunoblotting: comparison of different techniques. J. Immunol. Meth. 187: 259-63

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Martini E et al., (1988) Antibody to liver cytosol (anti-LC1) in patients with autoimmune chronic hepatitis type 2. Hepatol. 8:1662-6

Renous R et al.,(2004) Characterization of the antigenicity of the formiminotransferase-cyclodeaminase in type 2 autoimmune hepatitis. Exp. Cell Res. 292: 332-41