{"product_id":"lmnb1-polyclonal-antibody-e-ab-18237","title":"LMNB1 Polyclonal Antibody - E-AB-18237","description":"\u003cp\u003eLMNB1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-18237-60, E-AB-18237-120, E-AB-18237-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: LMNB1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: ADLD; lamin B1; Lamin-B1; LMN; LMN2; LMNB; Lmnb1; LMNB1; MGC111419; OTTHUMP00000159218\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Signal Transduction, Tags and Cell Markers\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P20700\u003c\/p\u003e\n\n\u003cp\u003eBackground: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD).\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.5 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Fusion protein of human LMNB1\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:1000-1:5000, IHC 1:100-1:300, ELISA 1:2000-1:10000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 67 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43143879917747,"sku":"E-AB-18237-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43143879950515,"sku":"E-AB-18237-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43143879983283,"sku":"E-AB-18237-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_edb2e107-1ebf-4161-873a-7cb979aece1d.png?v=1710242973","url":"https:\/\/afsbio.com\/products\/lmnb1-polyclonal-antibody-e-ab-18237","provider":"AFSBio Inc.","version":"1.0","type":"link"}