{"product_id":"ln28b-polyclonal-antibody-bt-ap10943","title":"LN28B Polyclonal Antibody - BT-AP10943","description":"\u003cp\u003eLN28B Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP10943-20, BT-AP10943-50, BT-AP10943-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3andapos; UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cancer; Epigenetics and nuclear signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: LIN28B\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Protein lin-28 homolog B\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q6ZN17; Mouse: Q45KJ6\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Protein lin-28 homolog B;Lin-28B\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 389421\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239204511923,"sku":"BT-AP10943-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239204544691,"sku":"BT-AP10943-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239204577459,"sku":"BT-AP10943-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_fd75e496-44d4-485f-888d-ad6def83f809.png?v=1769390567","url":"https:\/\/afsbio.com\/products\/ln28b-polyclonal-antibody-bt-ap10943","provider":"AFSBio Inc.","version":"1.0","type":"link"}