{"product_id":"lox-1-polyclonal-antibody-bs65855","title":"LOX 1 Polyclonal Antibody-BS65855","description":"LOX 1 Polyclonal Antibody\n\nProduct: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\n\nSizes: 50µl, 100µl\n\nCatalogue Numbers: BS65855-50, BS65855-100\n\nSwiss-Prot: Q9XTA8\n\nHost: Rabbit\n\nLOX 1 Polyclonal Antibody-BS65855\n\nStorage and Stability: Store at 4°C short term. Aliquot and store at -28°C long term. Avoid freeze-thaw cycles.\n\nReactivity: Human, Mouse, Rat, Cow, Rabbit,\n\nApplications: WB,\n\nAll Applications: WB=1:500-2000\n\nBackground: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.\n\nPurification and Purity: affinity purified by Protein A\n\nSpecificity: LOX 1 Polyclonal Antibody detects endogenous levels of LOX 1 protein.\n\nBioworld Molecular Weight: ~50 kDa\n\nNote: For research use only, not for use in diagnostic procedure.\n\nExtra Notes: Primary: Anti- LOX1 at 1\/300 dilution, Primary: Anti-LOX 1 at 1\/300 dilution\n\nAlternative Name: Lectin-type oxidized LDL receptor 1; OLR1; lectin-like low density lipoprotein receptor-1; Oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; Lectin-like oxidized LDL receptor 1; Lectin-like oxLDL receptor 1; LOX-1; BLOX1; Contains: Oxidized low-density lipoprotein receptor 1, soluble form A; Oxidized low-density lipoprotein receptor 1, soluble form B; OLR1_HUMAN.\n\nImmunogen: KLH conjugated synthetic peptide derived from rabbit LOX-1:201-273\/273\u003cextracellular\u003e\n\nModification: Unmodified\n\nConjugate: Unconjugated\u003c\/extracellular\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42962774065331,"sku":"BS65855-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42962774098099,"sku":"BS65855-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_9ef6cb46-6f8d-4fd8-9da6-24bf3def5f7a.jpg?v=1705318872","url":"https:\/\/afsbio.com\/products\/lox-1-polyclonal-antibody-bs65855","provider":"AFSBio Inc.","version":"1.0","type":"link"}