{"product_id":"lrig1-rabbit-pab-es11850","title":"LRIG1 rabbit pAb - ES11850","description":"\u003cp\u003eLRIG1 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES11850-50, ES11850-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: domain:The LRRs and the Ig-domains are each sufficient for EGFR\/ERBB1 binding. This interaction is abolished only when these two domains are deleted., function:Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation., induction:By EGF., similarity:Contains 17 LRR (leucine-rich) repeats., similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains., subunit:Interacts with EGFR\/ERBB1, ERBB2, ERBB3 and ERBB4., tissue specificity:Widely expressed.,\u003c\/p\u003e \n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from part region of human protein\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 120kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 26018\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q96JA1\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cell membrane; Single-pass type I membrane protein.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45201779949747,"sku":"ES11850-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45201779982515,"sku":"ES11850-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_014bfc43-b12f-485e-bbd6-4e044de8d11e.png?v=1767111623","url":"https:\/\/afsbio.com\/products\/lrig1-rabbit-pab-es11850","provider":"AFSBio Inc.","version":"1.0","type":"link"}