{"product_id":"lrp6-phospho-ser1490-rabbit-polyclonal-antibody-bt-ap11141","title":"LRP6 (Phospho-Ser1490) Rabbit Polyclonal Antibody - BT-AP11141","description":"\u003cp\u003eLRP6 (Phospho-Ser1490) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP11141-20, BT-AP11141-50, BT-AP11141-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or| with Frizzled| a co-receptor for Wnt and thereby transmits the canonical Wnt\/beta-catenin signaling cascade. Through its interaction with the Wnt\/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation| proliferation| and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: LRP6\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: LRP6\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: O75581; Mouse: O88572\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: LRP6;Ser1490; Low-density lipoprotein receptor-related protein 6; LRP-6\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 4040; Mouse: 16974\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239003283635,"sku":"BT-AP11141-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239003316403,"sku":"BT-AP11141-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239003349171,"sku":"BT-AP11141-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_2fbd7504-bee3-4d08-b11b-571358edf8a7.png?v=1769387828","url":"https:\/\/afsbio.com\/products\/lrp6-phospho-ser1490-rabbit-polyclonal-antibody-bt-ap11141","provider":"AFSBio Inc.","version":"1.0","type":"link"}