{"product_id":"lrp6-phospho-ser1490-rabbit-polyclonal-antibody-ra26925","title":"LRP6 (phospho-Ser1490) Rabbit Polyclonal Antibody - RA26925","description":"\u003cp\u003eLRP6 (phospho-Ser1490) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA26925-50, RA26925-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: LDL receptor related protein 6 (LRP6) Homo sapiens This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt\/beta-catenin signaling cascade. Through its interaction with the Wnt\/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: WB 1:1000-2000\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: Low-density lipoprotein receptor-related protein 6 (LRP-6)\u003c\/p\u003e \n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Rat; Mouse\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 4040\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 177\u003c\/p\u003e\n\n\u003cp\u003eSWISS: O75581\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121382056115,"sku":"RA26925-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121382088883,"sku":"RA26925-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_58af6ed7-c08f-4b88-b687-d5f7fe010f73.png?v=1773347050","url":"https:\/\/afsbio.com\/products\/lrp6-phospho-ser1490-rabbit-polyclonal-antibody-ra26925","provider":"AFSBio Inc.","version":"1.0","type":"link"}