{"product_id":"lrp6-polyclonal-antibody-e-ab-17347","title":"LRP6 Polyclonal Antibody - E-AB-17347","description":"\u003cp\u003eLRP6 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-17347-60, E-AB-17347-120, E-AB-17347-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: LRP6\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: ADCAD2; C030016K15Rik; Cd; FLJ90062; FLJ90421; LDL receptor related protein 6; Low density lipoprotein receptor related protein 6; Low-density lipoprotein receptor-related protein 6; LRP-6; LRP6; LRP6; OTTHUMP00000238979; OTTHUMP00000238980; OTTHUMP00000238982; STHAG7\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Signal transduction, Stem cells\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: O75581\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt\/beta-catenin signaling cascade. Through its interaction with the Wnt\/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1.4 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide of human LRP6\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:40-200, ELISA 1:2000-10000\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43130651017395,"sku":"E-AB-17347-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43130651050163,"sku":"E-AB-17347-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43130651082931,"sku":"E-AB-17347-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_15e2b1f6-90c9-4d75-ae09-37bb0dadb904.png?v=1709810770","url":"https:\/\/afsbio.com\/products\/lrp6-polyclonal-antibody-e-ab-17347","provider":"AFSBio Inc.","version":"1.0","type":"link"}