{"product_id":"lrrk1-polyclonal-antibody-bt-ap05082","title":"LRRK1 Polyclonal Antibody - BT-AP05082","description":"\u003cp\u003eLRRK1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP05082-20, BT-AP05082-50, BT-AP05082-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine\/threonine (Ser\/Thr) protein kinases. LRRK1 (leucine-rich repeat serine\/threonine-protein kinase 1), also known as RIPK6, Roco1 or KIAA1790, is a 2038 amino acid cytoplasmic protein that contains one protein kinase domain, four ANK repeats and 11 leucine-rich repeats and belongs to the Ser\/Thr protein kinase family. Using magnesium as a cofactor, LRRK1 catalyzes the ATP-dependent phosphorylation of target proteins. The gene encoding LRRK1, which is expressed as four alternatively spliced isoforms, is thought to be involved in the pathogenesis of Parkinson's disease.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: LRRK1\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: LRRK1 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 227843\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q38SD2; Mouse: Q3UHC2\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: LRRK1; KIAA1790; Leucine-rich repeat serine\/threonine-protein kinase 1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 79705\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239666049203,"sku":"BT-AP05082-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239666081971,"sku":"BT-AP05082-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239666114739,"sku":"BT-AP05082-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_953601f8-8ac1-49a3-9bb7-356b8f8c6eef.png?v=1769397794","url":"https:\/\/afsbio.com\/products\/lrrk1-polyclonal-antibody-bt-ap05082","provider":"AFSBio Inc.","version":"1.0","type":"link"}