{"product_id":"lrrk2-rabbit-monoclonal-antibody-bs40055","title":"LRRK2 Rabbit Monoclonal Antibody-BS40055","description":"\u003cp\u003eLRRK2 Rabbit Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS40055-50, BS40055-100\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q5S007\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eLRRK2 Rabbit Monoclonal Antibody-BS40055\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC ICC\/IF, IP,\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB 1:500~1:2000 IHC 1:50~1:200 ICC\/IF 1:50~1:200 IP 1:50\u003c\/p\u003e\n\n\u003cp\u003eBackground: Positively regulates autophagy through a calcium-dependent activation of the CaMKK\/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Affinity-chromatography\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: LRRK2 Antibody detects endogenous levels of total LRRK2\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 280kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of LRRK2 expression in U87-MG cell lysate., Immunohistochemical analysis of paraffin-embedded human thyroid, using LRRK2 Antibody.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: AURA17; Dardarin antibody; Leucine rich repeat kinase 2; LRRK 2 antibody; LRRK2; LRRK2_HUMAN; PARK 8; PARK8; RIPK7; ROCO 2; ROCO2;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: A synthesized peptide derived from human LRRK2\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42957262520499,"sku":"BS40055-50","price":276.71,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42957262553267,"sku":"BS40055-100","price":490.83,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_b85a1299-c50a-402c-849c-d583a417facd.jpg?v=1705144177","url":"https:\/\/afsbio.com\/products\/lrrk2-rabbit-monoclonal-antibody-bs40055","provider":"AFSBio Inc.","version":"1.0","type":"link"}