{"product_id":"macc1-rabbit-polyclonal-antibody-es4022","title":"MACC1 Rabbit Polyclonal Antibody - ES4022","description":"\u003cp\u003eMACC1 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES4022-50, ES4022-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: approximately 7-10 business days, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009],\u003c\/p\u003e \n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: MACC1; Metastasis-associated in colon cancer protein 1; SH3 domain-containing protein 7a5\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human MACC1. AA range:411-460\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: MACC1,\u003c\/p\u003e \n\n\u003cp\u003eSpecificity: MACC1 Polyclonal Antibody detects endogenous levels of MACC1 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e \n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Preferentially expressed in metastasizing tumors.\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 97kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. Similarity: Contains 1 SH3 domain. Subcellular Location: Mainly found in the cytoplasm in non-metastasizing tumors. Tissue Specificity: Preferentially expressed in metastasizing tumors.\u003c\/p\u003e \n\n\u003cp\u003eSubcellular Location: Cytoplasm Nucleus Mainly found in the cytoplasm in non-metastasizing tumors.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: MACC1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Metastasis-associated in colon cancer protein 1\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 346389\u003c\/p\u003e\n\n\u003cp\u003eHuman SwissProt Number: Q6ZN28\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":45825495761075,"sku":"ES4022-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45825495793843,"sku":"ES4022-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk-biotechnology-logo-product.jpg?v=1786476023","url":"https:\/\/afsbio.com\/products\/macc1-rabbit-polyclonal-antibody-es4022","provider":"AFSBio Inc.","version":"1.0","type":"link"}