{"product_id":"machr-m4-p277-polyclonal-antibody-bs3236","title":"mAChR M4 (P277) Polyclonal Antibody-BS3236","description":"\u003cp\u003emAChR M4 (P277) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS3236-50, BS3236-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Muscarinic acetylcholine receptor M4,CHRM4\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P08173\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: The muscarinic acetylcholine receptors (mAChR) mediate a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels. The mAChRs transducer signals by coupling to G-proteins, which then modulate several downstream effector proteins and ion channels. Five mAChR subtypes have been identified, designated M1 to M5. The five receptor subtypes show distinct patterns of tissue distribution, as well as distinct pharmacological and functional properties.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: mAChR M4 (P277) polyclonal antibody detects endogenous levels of mAChR M4 protein\u003c\/p\u003e \n\n\u003cp\u003eBioworld Molecular Weight: ~ 53 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of mAChR M4 (P277) pAb at 1:500 dilution\u003cbr\u003e\nLane 1: H1792 whole cell lysate(40ug)\u003cbr\u003e\nLane 2: MCF-7 whole cell lysate(40ug)\u003cbr\u003e\nLane 3: K562 whole cell lysate(40ug)\u003cbr\u003e\nLane 4: C6 whole cell lysate(40ug)\u003cbr\u003e\nLane 5: SP2\/0 whole cell lysate(40ug)\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 241-290 of Human mAChR M4.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42911802851507,"sku":"BS3236-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42911802884275,"sku":"BS3236-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_5e435eac-7fd2-4a19-a492-9c2f04a4ac3d.jpg?v=1703179525","url":"https:\/\/afsbio.com\/products\/machr-m4-p277-polyclonal-antibody-bs3236","provider":"AFSBio Inc.","version":"1.0","type":"link"}