{"product_id":"maml2-polyclonal-antibody-bt-ap11089","title":"MAML2 Polyclonal Antibody - BT-AP11089","description":"\u003cp\u003eMAML2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP11089-20, BT-AP11089-50, BT-AP11089-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the p\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling; Stem cells\u003c\/p\u003e \n\n\u003cp\u003eTarget Protein: MAML2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Mastermind-like protein 2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q8IZL2\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Mastermind-like protein 2;Mam-2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 84441\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239214801075,"sku":"BT-AP11089-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239214833843,"sku":"BT-AP11089-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239214866611,"sku":"BT-AP11089-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_c1365f15-23e2-4565-b509-f1fe66f9d7b2.png?v=1769390683","url":"https:\/\/afsbio.com\/products\/maml2-polyclonal-antibody-bt-ap11089","provider":"AFSBio Inc.","version":"1.0","type":"link"}