{"product_id":"manf-polyclonal-antibody-e-ab-12987","title":"MANF Polyclonal Antibody - E-AB-12987","description":"\u003cp\u003eMANF Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-12987-60, E-AB-12987-120, E-AB-12987-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: MANF\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Arginine rich mutated in early stage tumors; Arginine rich protein; Arginine-rich protein; ARMET; ARMET protein; ARP; Manf; MANF; Mesencephalic astrocyte derived neurotrophic factor; Mesencephalic astrocyte-derived neurotrophic factor; MGC142148; MGC142150; Protein ARMET\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P55145\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide of human MANF\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:100-1:300\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"200μL","offer_id":43124108624051,"sku":"E-AB-12987-200","price":558.6,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43124108656819,"sku":"E-AB-12987-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"60μL","offer_id":43124108689587,"sku":"E-AB-12987-60","price":200.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_ae30c451-e85d-44b0-b958-519589c00e23.png?v=1709724084","url":"https:\/\/afsbio.com\/products\/manf-polyclonal-antibody-e-ab-12987","provider":"AFSBio Inc.","version":"1.0","type":"link"}