{"product_id":"map2k4-monoclonal-antibody-bt-mca2146","title":"MAP2K4 Monoclonal Antibody - BT-MCA2146","description":"\u003cp\u003eMAP2K4 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2146-50, BT-MCA2146-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a dual specificity protein kinase that belongs to the Ser\/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8\/JNK1, MAPK9\/JNK2, and MAPK14\/p38, but not MAPK1\/ERK2 or MAPK3\/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1\/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.Tissue specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues .\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MAP2K4\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 5H4\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: MAP2K4\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human MAP2K4 expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 42kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P45985\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: JNKK, MEK4, MKK4, SEK1, JNKK1, SERK1, MAPKK4, PRKMK4, MAP2K4\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 6416\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238606430387,"sku":"BT-MCA2146-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238606463155,"sku":"BT-MCA2146-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_c8a2493a-938b-423a-89ae-2832a54b4a74.png?v=1769382998","url":"https:\/\/afsbio.com\/products\/map2k4-monoclonal-antibody-bt-mca2146","provider":"AFSBio Inc.","version":"1.0","type":"link"}