{"product_id":"map3k8-polyclonal-antibody-e-ab-91223","title":"MAP3K8 Polyclonal Antibody - E-AB-91223","description":"\u003cp\u003eMAP3K8 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-91223-60, E-AB-91223-120, E-AB-91223-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: MAP3K8\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: MAP3K8; AURA2; COT; EST; ESTF; MEKK8; TPL2; Tpl-2; c-COT\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P41279\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene is an oncogene that encodes a member of the serine\/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human MAP3K8\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 49kDa\/52kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 52KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146595401907,"sku":"E-AB-91223-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146595434675,"sku":"E-AB-91223-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146595467443,"sku":"E-AB-91223-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_3998bc70-ae16-4692-9e08-6785f19ee2db.png?v=1710298088","url":"https:\/\/afsbio.com\/products\/map3k8-polyclonal-antibody-e-ab-91223","provider":"AFSBio Inc.","version":"1.0","type":"link"}