{"product_id":"map4k4-monoclonal-antibody-bt-mca3123","title":"MAP4K4 Monoclonal Antibody - BT-MCA3123","description":"\u003cp\u003eMAP4K4 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA3123-50, BT-MCA3123-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4. The protein encoded by this gene is a member of the serine\/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8\/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7\/TAK1, MAP2K4\/MKK4, and MAP2K7\/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MAP4K4\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 4H9E7\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: MAP4K4\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of MAP4K4 (aa400-500) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: O95819\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: HGK, NIK\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 9448\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238367355059,"sku":"BT-MCA3123-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238367387827,"sku":"BT-MCA3123-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_ad3ebdc4-e7b2-4595-a372-83cfd55aa9a5.png?v=1769379244","url":"https:\/\/afsbio.com\/products\/map4k4-monoclonal-antibody-bt-mca3123","provider":"AFSBio Inc.","version":"1.0","type":"link"}