{"product_id":"map4k4-polyclonal-antibody-e-ab-90296","title":"MAP4K4 Polyclonal Antibody - E-AB-90296","description":"\u003cp\u003eMAP4K4 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-90296-60, E-AB-90296-120, E-AB-90296-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: MAP4K4\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: MAP4K4; FLH21957; HEL-S-31; HGK; MEKKK4; NIK\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: O95819\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the serine\/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8\/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7\/TAK1, MAP2K4\/MKK4, and MAP2K7\/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human MAP4K4\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 133kDa\/138kDa\/141kDa\/142kDa\/145kDa\/150kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 142kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146543628467,"sku":"E-AB-90296-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146543661235,"sku":"E-AB-90296-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146543694003,"sku":"E-AB-90296-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_0944ca0c-cb80-4d58-84ed-70d8dad329d4.png?v=1710297150","url":"https:\/\/afsbio.com\/products\/map4k4-polyclonal-antibody-e-ab-90296","provider":"AFSBio Inc.","version":"1.0","type":"link"}