{"product_id":"mapk8-monoclonal-antibody-bt-mca3361","title":"MAPK8 Monoclonal Antibody - BT-MCA3361","description":"\u003cp\u003eMAPK8 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA3361-50, BT-MCA3361-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Others\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MAPK8\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 1E5\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: MAPK8\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human MAPK8 expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 48.3kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P45983\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: JNK, JNK1, PRKM8, SAPK1, JNK-46, JNK1A2, SAPK1c, JNK21B1\/2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 5599\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238576808115,"sku":"BT-MCA3361-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238576840883,"sku":"BT-MCA3361-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_9198f36b-6c41-4174-962d-653057ae666c.png?v=1769382742","url":"https:\/\/afsbio.com\/products\/mapk8-monoclonal-antibody-bt-mca3361","provider":"AFSBio Inc.","version":"1.0","type":"link"}